Diagnostic Accuracy of Prostatic Specific Antigen Densityin Different Prostatic Disorders

Objective: To determine the diagnostic accuracy of PSA density in Prostate Cancer, Benign Prostatic Hyperplasia (BPH) and Prostatitis, taking biopsy as gold standard.
 Study Design: Cross-sectional study.
 Place Duration Study: Chemical Pathology Endocrinology Department, Armed Forces Institute (AFIP) collaboration with Histopathology department, AFIP, Urology (AFIU) Radiology (AFIRI) Rawalpindi Pakistan from Mar 2019 to 2020.
 Methodology: Prostate-specific antigen was analyzed on a fully automated random-access immunoassay-ADVIA® Centaur XP. volume measured through transrectal imaging technique, prostate obtained by dividing total volume. Specificity sensitivity, along positive predictive negative value both (PSAD), were calculated. In addition, Receiver Operating Characteristic (ROC) curve plotted for separately.
 Results: Overall, 129 subjects registered study. Out these individuals, 59 (45.7%) had cancer, 52 (40.3 %) benign prostatic hyperplasia (BPH), 14% other disorders. Total (PSA) sensitivity 75.61% specificity 76% while showed 88% 86% specificity. The area under (AUC) 0.66, that (PSAD) 0.87.
 Conclusion: is better non-invasive marker different disorders than antigen. It has.......